In the article presented by D. Decraene et algives an overview of the functions and roles of p53 gene. P53 is a tumor suppressor gene that protects against cancer by regulating cells that are subject to damages. The gene it is located on the short arm of chromosome 17. One of the most important roles of p53 is to protect the human skin from UV light. The gene is activated in the presence of UV light. The experiment is carried out to see the activation of p53 protein by observing the human skin cells when the cells are exposed to stimulated solar radiation. When the skin is not exposed to UV light, the p53 cannot be detected. Once UV light started to radiate onto human skins, an accumulation of p53 protein started to form in the epidermis. The p53 protein appears to be in its highest concentration after 2 hours of exposure to the radiation. The build up of p53 protein plays a pivotal part in protecting skin cells from mutation, DNA damage, growth arrest, DNA repair and apoptosis.
